Several investigators have shown that the radiographic contrast media have the ability to influence different biologic systems in blood. However, the influence of contrast media on the subpopulations of T-lymphocyte is scarcely investiagted. The
immune
response, including the production of immunoglobulin by B cells, is controlled in part by regulatory signals exchanged between functionally heterogenous subpopulation in the T-cell compartment. To evaluate the influence of contrast media on the
subpopulations of T-lymphocyte, the author studied the change of T-lymphocyte subpopulation in peripheral blood of 12 patients, before and after injection of fopromide(Ultravist(r)) in vivo during angiography. T-lymphocyte subpopulations were
analyzed
by flow cytometer, In general, lymphcyte, Anti-CD3+, Anti-CD4+, Anti-CD8+, Anti-CD45R+, and Anti-CD8 ratio statistically were not decreased by Iopromide. In conclusion, our results suggest that human immune system is not influenced by Iopromide
during
angiography.
Index words: Contract media, comparative studies contrast media, complications
Contrast media, toxicity Contrast media, effects
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